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Research Article

Protease-Sensitive Synthetic Prions

  • David W. Colby,

    Affiliation: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

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  • Rachel Wain,

    Affiliation: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

    Current address: British Veterinary Association, London, United Kingdom

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  • Ilia V. Baskakov,

    Affiliation: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

    Current address: Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland, United States of America

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  • Giuseppe Legname,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

    Current address: Neurobiology Sector, Scuola Internazionale di Studi Avanzati, Trieste, Italy

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  • Christina G. Palmer,

    Affiliation: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

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  • Hoang-Oanh B. Nguyen,

    Affiliation: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America

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  • Azucena Lemus,

    Affiliation: Department of Pathology, University of California, San Francisco, California, United States of America

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  • Fred E. Cohen,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Stephen J. DeArmond,

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Pathology, University of California, San Francisco, California, United States of America

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  • Stanley B. Prusiner mail

    stanley@ind.ucsf.edu

    Affiliations: Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America, Department of Neurology, University of California, San Francisco, California, United States of America

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  • Published: January 22, 2010
  • DOI: 10.1371/journal.ppat.1000736

About the Authors

David W. Colby, Rachel Wain, Ilia V. Baskakov, Giuseppe Legname, Christina G. Palmer, Hoang-Oanh B. Nguyen, Fred E. Cohen, Stephen J. DeArmond, Stanley B. Prusiner
Institute for Neurodegenerative Diseases, University of California, San Francisco, California, United States of America
Giuseppe Legname, Stanley B. Prusiner
Department of Neurology, University of California, San Francisco, California, United States of America
Azucena Lemus, Stephen J. DeArmond
Department of Pathology, University of California, San Francisco, California, United States of America
Fred E. Cohen
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

Corresponding Author

Email: stanley@ind.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DWC RW IVB GL FEC SBP. Performed the experiments: DWC RW CGP HOBN AL SJD. Analyzed the data: DWC RW AL SJD SBP. Contributed reagents/materials/analysis tools: FEC. Wrote the paper: DWC SJD SBP.