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Research Article

Upregulation of xCT by KSHV-Encoded microRNAs Facilitates KSHV Dissemination and Persistence in an Environment of Oxidative Stress

  • Zhiqiang Qin,

    Affiliations: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Craniofacial Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Eduardo Freitas,

    Affiliation: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Roger Sullivan,

    Affiliation: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Sarumathi Mohan,

    Affiliation: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Rocky Bacelieri,

    Affiliation: Department of Dermatology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Drake Branch,

    Affiliation: Department of Dermatology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Margaret Romano,

    Affiliation: Department of Pathology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

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  • Patricia Kearney,

    Affiliation: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Jim Oates,

    Affiliations: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, Medical Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, United States of America

    X
  • Karlie Plaisance,

    Affiliation: Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, Florida, United States of America

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  • Rolf Renne,

    Affiliation: Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, Florida, United States of America

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  • Johnan Kaleeba mail,

    jkaleeba@usuhs.mil (JK); parsonch@musc.edu (CP)

    Affiliation: Departments of Microbiology and Immunology and Molecular/Cell Biology, Uniformed Services University of the Health Sciences, F. Edward Herbert School of Medicine, Bethesda, Maryland, United States of America

    X
  • Chris Parsons mail

    jkaleeba@usuhs.mil (JK); parsonch@musc.edu (CP)

    Affiliations: Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Craniofacial Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Published: January 29, 2010
  • DOI: 10.1371/journal.ppat.1000742

About the Authors

Zhiqiang Qin, Eduardo Freitas, Roger Sullivan, Sarumathi Mohan, Patricia Kearney, Jim Oates, Chris Parsons
Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
Zhiqiang Qin, Chris Parsons
Department of Craniofacial Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
Rocky Bacelieri, Drake Branch
Department of Dermatology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
Margaret Romano
Department of Pathology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
Jim Oates
Medical Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, United States of America
Karlie Plaisance, Rolf Renne
Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, Florida, United States of America
Johnan Kaleeba
Departments of Microbiology and Immunology and Molecular/Cell Biology, Uniformed Services University of the Health Sciences, F. Edward Herbert School of Medicine, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZQ RR JK CP. Performed the experiments: ZQ EF RS SM MR PK KP. Analyzed the data: ZQ RB DB CP. Contributed reagents/materials/analysis tools: JO JK. Wrote the paper: ZQ RR CP. Contributed to paper editing: JK.