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Research Article

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

  • Kevin N. Couper mail,

    kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Tom Barnes,

    Affiliations: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

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  • Julius C. R. Hafalla,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Valery Combes,

    Affiliation: Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia

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  • Bernhard Ryffel,

    Affiliation: Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France

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  • Thomas Secher,

    Affiliation: Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France

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  • Georges E. Grau,

    Affiliation: Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia

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  • Eleanor M. Riley,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • J. Brian de Souza mail

    kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

    Affiliations: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

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  • Published: January 29, 2010
  • DOI: 10.1371/journal.ppat.1000744

About the Authors

Kevin N. Couper, Tom Barnes, Julius C. R. Hafalla, Eleanor M. Riley, J. Brian de Souza
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Tom Barnes, J. Brian de Souza
Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom
Valery Combes, Georges E. Grau
Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia
Bernhard Ryffel, Thomas Secher
Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KNC JBdS. Performed the experiments: KNC TB JCRH VC JBdS. Analyzed the data: KNC TB JBdS. Contributed reagents/materials/analysis tools: BR TS GEG EMR. Wrote the paper: KNC EMR JBdS.