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Research Article

Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host

  • Colin A. Cooper,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Kun Zhang,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Sara N. Andres,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Yuan Fang,

    Affiliation: Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Natalia A. Kaniuk,

    Affiliation: Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Mandy Hannemann,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Current address: International Max Planck Research School for Molecular Biology, Göttingen, Germany

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  • John H. Brumell,

    Affiliations: Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics and the Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Leonard J. Foster,

    Affiliation: Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Murray S. Junop,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Brian K. Coombes mail

    coombes@mcmaster.ca

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Published: February 05, 2010
  • DOI: 10.1371/journal.ppat.1000751

About the Authors

Colin A. Cooper, Kun Zhang, Sara N. Andres, Mandy Hannemann, Murray S. Junop, Brian K. Coombes
Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Yuan Fang, Leonard J. Foster
Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Natalia A. Kaniuk, John H. Brumell
Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
John H. Brumell
Department of Molecular Genetics and the Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: coombes@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAC KZ NAK MH JHB LJF MSJ BKC. Performed the experiments: CAC KZ YF NAK MH MSJ. Analyzed the data: CAC KZ SNA YF NAK MH JHB LJF MSJ BKC. Contributed reagents/materials/analysis tools: SNA LJF. Wrote the paper: CAC NAK JHB LJF MSJ BKC.