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Research Article

Reverse Genetics in Candida albicans Predicts ARF Cycling Is Essential for Drug Resistance and Virulence

  • Elias Epp,

    Affiliations: Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, Canada, Department of Biology, McGill University, Montréal, Québec, Canada

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  • Ghyslaine Vanier,

    Affiliation: Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada

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  • Doreen Harcus,

    Affiliation: Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, Canada

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  • Anna Y. Lee,

    Affiliation: McGill Centre for Bioinformatics, McGill University, Montréal, Québec, Canada

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  • Gregor Jansen,

    Affiliation: Department of Biochemistry, McGill University, Montréal, Québec, Canada

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  • Michael Hallett,

    Affiliation: McGill Centre for Bioinformatics, McGill University, Montréal, Québec, Canada

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  • Don C. Sheppard,

    Affiliation: Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada

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  • David Y. Thomas,

    Affiliation: Department of Biochemistry, McGill University, Montréal, Québec, Canada

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  • Carol A. Munro,

    Affiliation: School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Alaka Mullick,

    Affiliations: Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, Canada, Département de Microbiologie et Immunologie, l'Université de Montréal, Montréal, Québec, Canada

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  • Malcolm Whiteway mail

    malcolm.whiteway@cnrc-nrc.gc.ca

    Affiliations: Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, Canada, Department of Biology, McGill University, Montréal, Québec, Canada

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  • Published: February 05, 2010
  • DOI: 10.1371/journal.ppat.1000753

About the Authors

Elias Epp, Doreen Harcus, Alaka Mullick, Malcolm Whiteway
Biotechnology Research Institute, National Research Council of Canada, Montréal, Québec, Canada
Elias Epp, Malcolm Whiteway
Department of Biology, McGill University, Montréal, Québec, Canada
Ghyslaine Vanier, Don C. Sheppard
Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada
Anna Y. Lee, Michael Hallett
McGill Centre for Bioinformatics, McGill University, Montréal, Québec, Canada
Gregor Jansen, David Y. Thomas
Department of Biochemistry, McGill University, Montréal, Québec, Canada
Alaka Mullick
Département de Microbiologie et Immunologie, l'Université de Montréal, Montréal, Québec, Canada
Carol A. Munro
School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

Corresponding Author

Email: malcolm.whiteway@cnrc-nrc.gc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EE MW. Performed the experiments: EE GV CAM. Analyzed the data: EE. Contributed reagents/materials/analysis tools: DH AYL GJ MH DCS DYT CAM AM. Wrote the paper: EE.