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Research Article

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

  • Mehul S. Suthar,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Daphne Y. Ma equal contributor,

    equal contributor Contributed equally to this work with: Daphne Y. Ma, Sunil Thomas

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Sunil Thomas equal contributor,

    equal contributor Contributed equally to this work with: Daphne Y. Ma, Sunil Thomas

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Jennifer M. Lund,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    Current address: Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Nu Zhang,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Stephane Daffis,

    Affiliation: Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Alexander Y. Rudensky,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    Current address: Department of Immunology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Michael J. Bevan,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Edward A. Clark,

    Affiliations: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Murali-Krishna Kaja,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Michael S. Diamond,

    Affiliation: Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael Gale Jr mail

    mgale@u.washington.edu

    Affiliations: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Published: February 05, 2010
  • DOI: 10.1371/journal.ppat.1000757

About the Authors

Mehul S. Suthar, Daphne Y. Ma, Sunil Thomas, Jennifer M. Lund, Nu Zhang, Alexander Y. Rudensky, Michael J. Bevan, Edward A. Clark, Murali-Krishna Kaja, Michael Gale Jr
Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America
Stephane Daffis, Michael S. Diamond
Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Edward A. Clark, Michael Gale Jr
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Corresponding Author

Email: mgale@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MSS JML MG. Performed the experiments: MSS DYM ST JML MSD. Analyzed the data: MSS DYM JML NZ SD AR MB EAC MK MSD MG. Contributed reagents/materials/analysis tools: JML NZ SD AR MB EAC MK. Wrote the paper: MSS MG.