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Research Article

Highly Differentiated, Resting Gn-Specific Memory CD8+ T Cells Persist Years after Infection by Andes Hantavirus

  • Tobias Manigold mail,

    tmanigold@gmail.com

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

    Current address: Hoffmann-La Roche, Basel, Switzerland

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  • Andrés Mori,

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

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  • Rebecca Graumann,

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

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  • Elena Llop,

    Affiliation: Facultad de Medicina, Universidad de Chile, Santiago, Chile

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  • Valeska Simon,

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

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  • Marcela Ferrés,

    Affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

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  • Francisca Valdivieso,

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

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  • Constanza Castillo,

    Affiliation: Universidad de la Frontera, Temuco, Chile

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  • Brian Hjelle,

    Affiliation: University of New Mexico, Albuquerque, New Mexico, United States of America

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  • Pablo Vial

    Affiliation: Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile

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  • Published: February 19, 2010
  • DOI: 10.1371/journal.ppat.1000779

About the Authors

Tobias Manigold, Andrés Mori, Rebecca Graumann, Valeska Simon, Francisca Valdivieso, Pablo Vial
Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile
Elena Llop
Facultad de Medicina, Universidad de Chile, Santiago, Chile
Marcela Ferrés
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
Constanza Castillo
Universidad de la Frontera, Temuco, Chile
Brian Hjelle
University of New Mexico, Albuquerque, New Mexico, United States of America

Corresponding Author

Email: tmanigold@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM MF FV CC BH PV. Performed the experiments: TM AM RG VS. Analyzed the data: TM AM RG EL MF BH. Contributed reagents/materials/analysis tools: VS. Wrote the paper: TM AM EL VS FV CC BH PV.