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Research Article

Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8+ T-Cells with Cytotoxic as well as Regulatory Activity

  • Simone A. Joosten equal contributor,

    equal contributor Contributed equally to this work with: Simone A. Joosten, Krista E. van Meijgaarden

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Krista E. van Meijgaarden equal contributor,

    equal contributor Contributed equally to this work with: Simone A. Joosten, Krista E. van Meijgaarden

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Pascale C. van Weeren,

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Fatima Kazi,

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Annemieke Geluk,

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Nigel D. L. Savage,

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Jan W. Drijfhout,

    Affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

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  • Darren R. Flower,

    Affiliation: The Jenner Institute, University of Oxford, Oxford, United Kingdom

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  • Willem A. Hanekom,

    Affiliation: South African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa

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  • Michèl R. Klein,

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

    Current address: National Institute for Public Health and the Environment, Bilthoven, The Netherlands

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  • Tom H. M. Ottenhoff mail

    t.h.m.ottenhoff@lumc.nl

    Affiliation: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.ppat.1000782

About the Authors

Simone A. Joosten, Krista E. van Meijgaarden, Pascale C. van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D. L. Savage, Michèl R. Klein, Tom H. M. Ottenhoff
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Jan W. Drijfhout
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Darren R. Flower
The Jenner Institute, University of Oxford, Oxford, United Kingdom
Willem A. Hanekom
South African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa

Corresponding Author

Email: t.h.m.ottenhoff@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAJ KEvM FK AG DRF MRK. Performed the experiments: SAJ KEvM PCvW FK. Analyzed the data: SAJ KEvM AG NDLS THMO. Contributed reagents/materials/analysis tools: JWD DRF WAH. Wrote the paper: SAJ THMO.