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Research Article

Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis

  • Viveka Vadyvaloo,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

    Current address: Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington, United States of America

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  • Clayton Jarrett,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Daniel E. Sturdevant,

    Affiliation: Genomics Unit, Research Technologies Section; Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Florent Sebbane,

    Affiliation: Institut National de la Santé et de la Recherche Médicale U801, Institut Pasteur de Lille, and Université Lille Nord de France, Lille, France

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  • B. Joseph Hinnebusch mail

    jhinnebusch@niaid.nih.gov

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.ppat.1000783

About the Authors

Viveka Vadyvaloo, Clayton Jarrett, B. Joseph Hinnebusch
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Daniel E. Sturdevant
Genomics Unit, Research Technologies Section; Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Florent Sebbane
Institut National de la Santé et de la Recherche Médicale U801, Institut Pasteur de Lille, and Université Lille Nord de France, Lille, France

Corresponding Author

Email: jhinnebusch@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VV DES FS BJH. Performed the experiments: VV CJ BJH. Analyzed the data: VV CJ DES FS BJH. Contributed reagents/materials/analysis tools: DES FS. Wrote the paper: VV DES BJH.