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Research Article

Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses

  • Maki Kiso,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan

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  • Shuku Kubo,

    Affiliation: Biological Research Laboratories, Daiichi Sankyo Co. Ltd., Hiromachi, Shinagawa-ku, Tokyo, Japan

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  • Makoto Ozawa,

    Affiliations: International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Quynh Mai Le,

    Affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

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  • Chairul A. Nidom,

    Affiliation: Faculty of Veterinary Medicine, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia

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  • Makoto Yamashita,

    Affiliation: Biological Research Laboratories, Daiichi Sankyo Co. Ltd., Hiromachi, Shinagawa-ku, Tokyo, Japan

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  • Yoshihiro Kawaoka mail

    kawaoka@ims.u-tokyo.ac.jp

    Affiliations: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan, Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan, International Center for Medical Research and Treatment, Graduate School of Medicine, Kobe University, Chuo-ku, Hyogo, Japan

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.ppat.1000786

About the Authors

Maki Kiso, Yoshihiro Kawaoka
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan
Shuku Kubo, Makoto Yamashita
Biological Research Laboratories, Daiichi Sankyo Co. Ltd., Hiromachi, Shinagawa-ku, Tokyo, Japan
Makoto Ozawa, Yoshihiro Kawaoka
International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan
Makoto Ozawa, Yoshihiro Kawaoka
Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
Quynh Mai Le
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Chairul A. Nidom
Faculty of Veterinary Medicine, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia
Yoshihiro Kawaoka
ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan
Yoshihiro Kawaoka
International Center for Medical Research and Treatment, Graduate School of Medicine, Kobe University, Chuo-ku, Hyogo, Japan

Corresponding Author

Email: kawaoka@ims.u-tokyo.ac.jp

Competing Interests

YK has received speaker's honoraria from Chugai Pharmaceuticals, Novartis, Diichi-Sankyo, Toyama Chemical, Wyeth, and GlaxoSmithKline; grant support from Chugai Pharmaceuticals, Daiichi Sankyo Pharmaceutical, and Toyama Chemical; and is a founder of FluGen.

Author Contributions

Conceived and designed the experiments: MK MY YK. Performed the experiments: MK SK MO MY. Analyzed the data: MK SK MO MY YK. Contributed reagents/materials/analysis tools: QML CAN. Wrote the paper: MK SK MO MY YK.