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Research Article

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

  • Tadaki Suzuki,

    Affiliation: Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

    Current address: Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

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  • Yasuko Orba,

    Affiliations: Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan, Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan

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  • Yuki Okada,

    Affiliation: Career-Path Promotion Unit for Young Life Scientists, ICDO, Kyoto University, Kyoto, Japan

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  • Yuji Sunden,

    Affiliation: Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Japan

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  • Takashi Kimura,

    Affiliation: Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

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  • Shinya Tanaka,

    Affiliation: Laboratory of Cancer Research, Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan

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  • Kazuo Nagashima,

    Affiliation: Laboratory of Cancer Research, Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan

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  • William W. Hall,

    Affiliation: Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland

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  • Hirofumi Sawa mail

    h-sawa@czc.hokudai.ac.jp

    Affiliations: Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan, Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan

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  • Published: March 12, 2010
  • DOI: 10.1371/journal.ppat.1000801

About the Authors

Tadaki Suzuki, Yasuko Orba, Takashi Kimura, Hirofumi Sawa
Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan
Yasuko Orba, Hirofumi Sawa
Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan
Yuki Okada
Career-Path Promotion Unit for Young Life Scientists, ICDO, Kyoto University, Kyoto, Japan
Yuji Sunden
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Japan
Shinya Tanaka, Kazuo Nagashima
Laboratory of Cancer Research, Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan
William W. Hall
Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland

Corresponding Author

Email: h-sawa@czc.hokudai.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: T. Suzuki, Y. Orba, Y. Okada, T. Kimura, S. Tanaka, K. Nagashima, W. Hall, H. Sawa. Performed the experiments: T. Suzuki, Y. Orba, Y. Okada, Y. Sunden. Analyzed the data: T. Suzuki, Y. Orba, Y. Okada, Y. Sunden. Contributed reagents/materials/analysis tools: T. Suzuki, H. Sawa. Wrote the paper: T. Suzuki, H. Sawa.