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Research Article

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

  • Jacob G. Malone mail,

    jacob.malone@unibas.ch (JGM); urs.jenal@unibas.ch (UJ)

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Tina Jaeger,

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Christian Spangler,

    Affiliation: Institute of Pharmacology, Hannover Medical School, Hannover, Germany

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  • Daniel Ritz,

    Affiliation: Actelion Pharmaceuticals Ltd., Allschwil, Switzerland

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  • Anne Spang,

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Cécile Arrieumerlou,

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Volkhard Kaever,

    Affiliation: Institute of Pharmacology, Hannover Medical School, Hannover, Germany

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  • Regine Landmann,

    Affiliation: Department of Biomedicine, University Hospital, Basel, Switzerland

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  • Urs Jenal mail

    jacob.malone@unibas.ch (JGM); urs.jenal@unibas.ch (UJ)

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Published: March 12, 2010
  • DOI: 10.1371/journal.ppat.1000804

About the Authors

Jacob G. Malone, Tina Jaeger, Anne Spang, Cécile Arrieumerlou, Urs Jenal
Biozentrum, University of Basel, Basel, Switzerland
Christian Spangler, Volkhard Kaever
Institute of Pharmacology, Hannover Medical School, Hannover, Germany
Daniel Ritz
Actelion Pharmaceuticals Ltd., Allschwil, Switzerland
Regine Landmann
Department of Biomedicine, University Hospital, Basel, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JGM TJ DR AS CA RL UJ. Performed the experiments: JGM TJ CS VK. Analyzed the data: JGM TJ AS CA RL UJ. Contributed reagents/materials/analysis tools: CS VK. Wrote the paper: JGM TJ UJ.