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Research Article

An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses

  • Stephanie J. DeWitte-Orr,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Susan E. Collins,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Carla M. T. Bauer,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Dawn M. Bowdish,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Karen L. Mossman mail

    mossk@mcmaster.ca

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: March 26, 2010
  • DOI: 10.1371/journal.ppat.1000829

About the Authors

Stephanie J. DeWitte-Orr, Susan E. Collins, Carla M. T. Bauer, Dawn M. Bowdish, Karen L. Mossman
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: mossk@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJDO KLM. Performed the experiments: SJDO SEC CMTB. Analyzed the data: SJDO KLM. Contributed reagents/materials/analysis tools: DMB. Wrote the paper: SJDO KLM.