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Research Article

T Cell-Dependence of Lassa Fever Pathogenesis

  • Lukas Flatz equal contributor,

    equal contributor Contributed equally to this work with: Lukas Flatz, Toni Rieger, Doron Merkler

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland

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  • Toni Rieger equal contributor,

    equal contributor Contributed equally to this work with: Lukas Flatz, Toni Rieger, Doron Merkler

    Affiliation: Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

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  • Doron Merkler equal contributor,

    equal contributor Contributed equally to this work with: Lukas Flatz, Toni Rieger, Doron Merkler

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Andreas Bergthaler,

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland

    Current address: Institute for Systems Biology, Seattle, Washington, United States of America

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  • Tommy Regen,

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Mariann Schedensack,

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Lukas Bestmann,

    Affiliations: Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland, Unilabs Dr. Weber, St. Gallen, Switzerland

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  • Admar Verschoor,

    Affiliation: Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland

    Current address: Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany

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  • Mario Kreutzfeldt,

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Wolfgang Brück,

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Uwe-Karsten Hanisch,

    Affiliation: Department of Neuropathology, Georg-August-University, Göttingen, Germany

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  • Stephan Günther ,

    Affiliation: Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

    These authors contributed equally to this work.

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  • Daniel D. Pinschewer mail

    daniel.pinschewer@gmx.ch

    Affiliations: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland, Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland, W.H.O. Collaborating Center for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland

    These authors contributed equally to this work.

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  • Published: March 26, 2010
  • DOI: 10.1371/journal.ppat.1000836

About the Authors

Lukas Flatz, Andreas Bergthaler, Daniel D. Pinschewer
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
Lukas Flatz, Andreas Bergthaler, Admar Verschoor, Daniel D. Pinschewer
Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland
Toni Rieger, Stephan Günther
Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
Doron Merkler, Tommy Regen, Mariann Schedensack, Mario Kreutzfeldt, Wolfgang Brück, Uwe-Karsten Hanisch
Department of Neuropathology, Georg-August-University, Göttingen, Germany
Lukas Bestmann
Institute of Clinical Chemistry, University Hospital of Zurich, Zurich, Switzerland
Lukas Bestmann
Unilabs Dr. Weber, St. Gallen, Switzerland
Daniel D. Pinschewer
W.H.O. Collaborating Center for Neonatal Vaccinology, University of Geneva, Geneva, Switzerland

Corresponding Author

Email: daniel.pinschewer@gmx.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: L. Flatz, T. Rieger, D. Merkler, U. Hanisch, S. Günther, D. Pinschewer. Performed the experiments: L. Flatz, T. Rieger, D. Merkler, T. Regen, M. Schedensack, M. Kreutzfeldt. Analyzed the data: L. Flatz, T. Rieger, D. Merkler, T. Regen, M. Schedensack, L. Bestmann, U. Hanisch, S. Günther, D. Pinschewer. Contributed reagents/materials/analysis tools: A. Bergthaler, A. Verschoor, W. Brück. Wrote the paper: A. Verschoor, D. Pinschewer.