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Research Article

Junín Virus Infection of Human Hematopoietic Progenitors Impairs In Vitro Proplatelet Formation and Platelet Release via a Bystander Effect Involving Type I IFN Signaling

  • Roberto G. Pozner,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Agustín E. Ure,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Carolina Jaquenod de Giusti,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Lina P. D'Atri,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Joseph E. Italiano,

    Affiliations: Division of Translational Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Vascular Biology, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Oscar Torres,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Victor Romanowski,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Mirta Schattner mail,

    mschattner@hematologia.anm.edu.ar (MS); rmg@biol.unlp.edu.ar (RMG)

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

    These authors are joint senior authors on this work.

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  • Ricardo M. Gómez mail

    mschattner@hematologia.anm.edu.ar (MS); rmg@biol.unlp.edu.ar (RMG)

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

    These authors are joint senior authors on this work.

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  • Published: April 15, 2010
  • DOI: 10.1371/journal.ppat.1000847

About the Authors

Roberto G. Pozner, Lina P. D'Atri, Oscar Torres, Mirta Schattner
Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina
Agustín E. Ure, Carolina Jaquenod de Giusti, Victor Romanowski, Ricardo M. Gómez
Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina
Joseph E. Italiano
Division of Translational Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Joseph E. Italiano
Department of Vascular Biology, Children's Hospital Boston, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS RMG. Performed the experiments: RGP AEU CJdG LPD JEI. Analyzed the data: RGP JEI VR MS RMG. Contributed reagents/materials/analysis tools: OT. Wrote the paper: MS RMG.