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Research Article

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

  • Aisha Nazli,

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Olivia Chan,

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Wendy N. Dobson-Belaire,

    Affiliation: Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • Michel Ouellet,

    Affiliation: Department of Medical Biology, Laval University, Quebec City, Quebec, Canada

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  • Michel J. Tremblay,

    Affiliation: Department of Medical Biology, Laval University, Quebec City, Quebec, Canada

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  • Scott D. Gray-Owen,

    Affiliation: Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • A. Larry Arsenault,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Charu Kaushic mail

    kaushic@mcmaster.ca

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: April 08, 2010
  • DOI: 10.1371/journal.ppat.1000852

About the Authors

Aisha Nazli, Olivia Chan, Charu Kaushic
Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
Aisha Nazli, Olivia Chan, A. Larry Arsenault, Charu Kaushic
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Wendy N. Dobson-Belaire, Scott D. Gray-Owen
Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
Michel Ouellet, Michel J. Tremblay
Department of Medical Biology, Laval University, Quebec City, Quebec, Canada

Corresponding Author

Email: kaushic@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AN CK. Performed the experiments: AN OC. Analyzed the data: AN OC ALA CK. Contributed reagents/materials/analysis tools: WNDB MO MJT SDGO CK. Wrote the paper: AN CK.