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Research Article

Proteolysis of Human Thrombin Generates Novel Host Defense Peptides

  • Praveen Papareddy,

    Affiliation: Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden

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  • Victoria Rydengård,

    Affiliation: Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden

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  • Mukesh Pasupuleti,

    Affiliation: Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden

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  • Björn Walse,

    Affiliation: SARomics AB, Lund, Sweden

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  • Matthias Mörgelin,

    Affiliation: Division of Infection Medicine, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden

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  • Anna Chalupka,

    Affiliations: Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden, Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

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  • Martin Malmsten,

    Affiliation: Department of Pharmacy, Uppsala University, Biomedical Center, Uppsala, Sweden

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  • Artur Schmidtchen mail

    artur.schmidtchen@med.lu.se

    Affiliation: Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden

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  • Published: April 22, 2010
  • DOI: 10.1371/journal.ppat.1000857

About the Authors

Praveen Papareddy, Victoria Rydengård, Mukesh Pasupuleti, Anna Chalupka, Artur Schmidtchen
Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden
Björn Walse
SARomics AB, Lund, Sweden
Matthias Mörgelin
Division of Infection Medicine, Department of Clinical Sciences, Lund University, Biomedical Center, Lund, Sweden
Anna Chalupka
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland
Martin Malmsten
Department of Pharmacy, Uppsala University, Biomedical Center, Uppsala, Sweden

Corresponding Author

Email: artur.schmidtchen@med.lu.se

Competing Interests

Drs. Schmidtchen and Malmsten have shares in DermaGen AB and XImmune AB, companies involved in the therapeutic development of peptides for topical and systemic use, respectively.

Author Contributions

Conceived and designed the experiments: P. Papareddy, M. Malmsten, A. Schmidtchen. Performed the experiments: P. Papareddy, V. Rydengård, M. Pasupuleti, M. Mörgelin, A. Chalupka, M. Malmsten. Analyzed the data: P. Papareddy, V. Rydengård, B. Walse, M. Mörgelin, M. Malmsten, A. Schmidtchen. Contributed reagents/materials/analysis tools: A. Schmidtchen. Wrote the paper: A. Schmidtchen.