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Research Article

A Differential Role for Macropinocytosis in Mediating Entry of the Two Forms of Vaccinia Virus into Dendritic Cells

  • Kerrie J. Sandgren,

    Affiliations: Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia

    Current address: Center For Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • John Wilkinson,

    Affiliation: Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia

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  • Monica Miranda-Saksena,

    Affiliation: Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia

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  • Gerald M. McInerney,

    Affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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  • Karen Byth-Wilson,

    Affiliation: Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia

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  • Phillip J. Robinson,

    Affiliation: Children's Medical Research Institute, Westmead, Sydney, New South Wales, Australia

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  • Anthony L. Cunningham mail

    tony.cunningham@sydney.edu.au

    Affiliation: Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia

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  • Published: April 22, 2010
  • DOI: 10.1371/journal.ppat.1000866

About the Authors

Kerrie J. Sandgren, John Wilkinson, Monica Miranda-Saksena, Karen Byth-Wilson, Anthony L. Cunningham
Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia
Kerrie J. Sandgren
Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Gerald M. McInerney
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Phillip J. Robinson
Children's Medical Research Institute, Westmead, Sydney, New South Wales, Australia

Corresponding Author

Email: tony.cunningham@sydney.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJS JW ALC. Performed the experiments: KJS JW MMS GMM. Analyzed the data: KJS JW KBW. Contributed reagents/materials/analysis tools: PJR. Wrote the paper: KJS.