Advertisement
Research Article

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

  • Tsin W. Yeo mail,

    tsin.yeo@menzies.edu.au

    Affiliation: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

    X
  • Daniel A. Lampah,

    Affiliation: Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia

    X
  • Emiliana Tjitra,

    Affiliation: National Institute of Health Research and Development, Jakarta, Indonesia

    X
  • Retno Gitawati,

    Affiliation: National Institute of Health Research and Development, Jakarta, Indonesia

    X
  • Christabelle J. Darcy,

    Affiliation: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

    X
  • Catherine Jones,

    Affiliation: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

    X
  • Enny Kenangalem,

    Affiliation: Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia

    X
  • Yvette R. McNeil,

    Affiliation: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

    X
  • Donald L. Granger,

    Affiliation: Division of Infectious Diseases, University of Utah and VA Medical Centers, Salt Lake City, Utah, United States of America

    X
  • Bert K. Lopansri,

    Affiliations: Division of Infectious Diseases, University of Utah and VA Medical Centers, Salt Lake City, Utah, United States of America, Division of Infectious Disease, Loyola University Medical Center, Maywood, Illinois, United States of America

    X
  • J. Brice Weinberg,

    Affiliation: Division of Hematology-Oncology, Duke and VA Medical Centers, Durham, North Carolina, United States of America

    X
  • Ric N. Price,

    Affiliations: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Centre for Vaccinology & Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia

    X
  • Stephen B. Duffull,

    Affiliation: School of Pharmacy, University of Otago, Dunedin, New Zealand

    X
  • David S. Celermajer,

    Affiliation: Department of Medicine, University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

    X
  • Nicholas M. Anstey

    Affiliations: International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia

    X
  • Published: April 22, 2010
  • DOI: 10.1371/journal.ppat.1000868

About the Authors

Tsin W. Yeo, Christabelle J. Darcy, Catherine Jones, Yvette R. McNeil, Ric N. Price, Nicholas M. Anstey
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Daniel A. Lampah, Enny Kenangalem
Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
Emiliana Tjitra, Retno Gitawati
National Institute of Health Research and Development, Jakarta, Indonesia
Donald L. Granger, Bert K. Lopansri
Division of Infectious Diseases, University of Utah and VA Medical Centers, Salt Lake City, Utah, United States of America
Bert K. Lopansri
Division of Infectious Disease, Loyola University Medical Center, Maywood, Illinois, United States of America
J. Brice Weinberg
Division of Hematology-Oncology, Duke and VA Medical Centers, Durham, North Carolina, United States of America
Ric N. Price
Centre for Vaccinology & Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Ric N. Price, Nicholas M. Anstey
Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
Stephen B. Duffull
School of Pharmacy, University of Otago, Dunedin, New Zealand
David S. Celermajer
Department of Medicine, University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

Corresponding Author

Email: tsin.yeo@menzies.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TWY ET RG DLG BKL JBW RNP SBD DSC NMA. Performed the experiments: TWY DAL ET RG CJD CJ EK YRM NMA. Analyzed the data: TWY RNP NMA. Wrote the paper: TWY DAL ET RG CJD CJ EK YRM DLG BKL JBW RNP SBD DSC NMA.