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Research Article

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

  • Alexandra Schubert-Unkmeir mail,

    aunkmeir@hygiene.uni-wuerzburg.de

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Christian Konrad,

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Heiko Slanina,

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Florian Czapek,

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Sabrina Hebling,

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Matthias Frosch

    Affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

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  • Published: April 29, 2010
  • DOI: 10.1371/journal.ppat.1000874

About the Authors

Alexandra Schubert-Unkmeir, Christian Konrad, Heiko Slanina, Florian Czapek, Sabrina Hebling, Matthias Frosch
Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

Corresponding Author

Email: aunkmeir@hygiene.uni-wuerzburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ASU. Performed the experiments: ASU CK HS FC SH. Analyzed the data: ASU HS SH. Contributed reagents/materials/analysis tools: MF. Wrote the paper: ASU.