Advertisement
Research Article

Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

  • Ian A. Cockburn,

    Affiliation: Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Yun-Chi Chen,

    Affiliation: Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Michael G. Overstreet,

    Affiliation: Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    Current address: David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America

    X
  • Jason R. Lees,

    Affiliation: Department of Surgery, University of Maryland at Baltimore, Baltimore, Maryland, United States of America

    X
  • Nico van Rooijen,

    Affiliation: Vrije Universiteit, VUMC, Department of Molecular Cell Biology, Faculty of Medicine, Amsterdam, The Netherlands

    X
  • Donna L. Farber,

    Affiliation: Department of Surgery, University of Maryland at Baltimore, Baltimore, Maryland, United States of America

    X
  • Fidel Zavala mail

    fzavala@jhsph.edu

    Affiliation: Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Published: May 06, 2010
  • DOI: 10.1371/journal.ppat.1000877

About the Authors

Ian A. Cockburn, Yun-Chi Chen, Michael G. Overstreet, Fidel Zavala
Johns Hopkins Malaria Research Institute and Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Jason R. Lees, Donna L. Farber
Department of Surgery, University of Maryland at Baltimore, Baltimore, Maryland, United States of America
Nico van Rooijen
Vrije Universiteit, VUMC, Department of Molecular Cell Biology, Faculty of Medicine, Amsterdam, The Netherlands

Corresponding Author

Email: fzavala@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IAC YCC JRL DLF FZ. Performed the experiments: IAC YCC MGO JRL. Analyzed the data: IAC YCC MGO. Contributed reagents/materials/analysis tools: JRL NvR DLF. Wrote the paper: IAC FZ.