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Research Article

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

  • Lance D. Eckerle,

    Affiliation: Departments of Pediatrics and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Michelle M. Becker,

    Affiliation: Departments of Pediatrics and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Rebecca A. Halpin,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Kelvin Li,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Eli Venter,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Xiaotao Lu,

    Affiliation: Departments of Pediatrics and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Sana Scherbakova,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Rachel L. Graham,

    Affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Ralph S. Baric,

    Affiliations: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Timothy B. Stockwell,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • David J. Spiro,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Mark R. Denison mail

    mark.denison@vanderbilt.edu

    Affiliation: Departments of Pediatrics and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Published: May 06, 2010
  • DOI: 10.1371/journal.ppat.1000896

About the Authors

Lance D. Eckerle, Michelle M. Becker, Xiaotao Lu, Mark R. Denison
Departments of Pediatrics and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Rebecca A. Halpin, Kelvin Li, Eli Venter, Sana Scherbakova, Timothy B. Stockwell, David J. Spiro
The J. Craig Venter Institute, Rockville, Maryland, United States of America
Rachel L. Graham, Ralph S. Baric
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Ralph S. Baric
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: mark.denison@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LDE MMB MRD. Performed the experiments: LDE MMB RAH XL SS RLG. Analyzed the data: LDE KL EV RSB TBS DJS. Contributed reagents/materials/analysis tools: MMB KL EV RLG TBS DJS. Wrote the paper: LDE MMB MRD.