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Research Article

Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species

  • Lisa E. Hensley equal contributor,

    equal contributor Contributed equally to this work with: Lisa E. Hensley, Sabue Mulangu

    Affiliation: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Sabue Mulangu equal contributor,

    equal contributor Contributed equally to this work with: Lisa E. Hensley, Sabue Mulangu

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Clement Asiedu,

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Joshua Johnson,

    Affiliation: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Anna N. Honko,

    Affiliation: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Daphne Stanley,

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Giulia Fabozzi,

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Stuart T. Nichol,

    Affiliation: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Thomas G. Ksiazek,

    Affiliation: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    Current address: University of Texas Medical Branch, Galveston National Laboratory, Galveston, Texas, United States of America

    X
  • Pierre E. Rollin,

    Affiliation: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Victoria Wahl-Jensen,

    Affiliation: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America

    X
  • Michael Bailey,

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Peter B. Jahrling,

    Affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Mario Roederer,

    Affiliation: Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Richard A. Koup,

    Affiliation: Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Nancy J. Sullivan mail

    nsullivan@nih.gov

    Affiliation: Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: May 20, 2010
  • DOI: 10.1371/journal.ppat.1000904

About the Authors

Lisa E. Hensley, Joshua Johnson, Anna N. Honko, Victoria Wahl-Jensen
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
Sabue Mulangu, Clement Asiedu, Daphne Stanley, Giulia Fabozzi, Michael Bailey, Nancy J. Sullivan
Biodefense Research Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
Stuart T. Nichol, Thomas G. Ksiazek, Pierre E. Rollin
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Peter B. Jahrling
Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Mario Roederer, Richard A. Koup
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: nsullivan@nih.gov

Competing Interests

NJS and PBJ are named on patent applications for Ebola vaccines.

Author Contributions

Conceived and designed the experiments: LEH SM RAK NJS. Performed the experiments: LEH SM CA JJ ANH DS GF VWJ MB NJS. Analyzed the data: SM NJS. Contributed reagents/materials/analysis tools: STN TGK PER PBJ MR. Wrote the paper: CA NJS. Animal protocol assistance: VWJ.