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Research Article

The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections

  • Greta E. Weiss,

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Boubacar Traore,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Kassoum Kayentao,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Aissata Ongoiba,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Safiatou Doumbo,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Didier Doumtabe,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Younoussou Kone,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Seydou Dia,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Agnes Guindo,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Abdramane Traore,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

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  • Chiung-Yu Huang,

    Affiliation: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kazutoyo Miura,

    Affiliation: Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Marko Mircetic,

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Shanping Li,

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Amy Baughman,

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • David L. Narum,

    Affiliation: Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Louis H. Miller,

    Affiliation: Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ogobara K. Doumbo,

    Affiliation: Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

    X
  • Susan K. Pierce mail,

    spierce@niaid.nih.gov (SKP); pcrompton@niaid.nih.gov (PDC)

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Peter D. Crompton mail

    spierce@niaid.nih.gov (SKP); pcrompton@niaid.nih.gov (PDC)

    Affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: May 20, 2010
  • DOI: 10.1371/journal.ppat.1000912

About the Authors

Greta E. Weiss, Marko Mircetic, Shanping Li, Amy Baughman, Susan K. Pierce, Peter D. Crompton
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Boubacar Traore, Kassoum Kayentao, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabe, Younoussou Kone, Seydou Dia, Agnes Guindo, Abdramane Traore, Ogobara K. Doumbo
Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
Chiung-Yu Huang
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Kazutoyo Miura, David L. Narum, Louis H. Miller
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: G. Weiss, B. Traore, K. Kayentao, A. Ongoiba, L. Miller, O. Doumbo, S. Pierce, P. Crompton. Performed the experiments: G. Weiss, S. Doumbo, D. Doumtabe, Y. Kone, S. Dia, A. Guindo, A. Ttraore, M. Mircetic, S. Li, A. Baughman, P. Crompton. Analyzed the data: G. Weiss, P. Crompton. Contributed reagents/materials/analysis tools: C. Huang, K. Miura, D. Narum. Wrote the paper: G. Weiss, S. Pierce, P. Crompton. Provided medical care for study participants and collected clinical data at the field site: K. Kayentao, A. Ongoiba, Y. Kone, S. Dia. Processed biological specimens and performed clinical assays: S. Doumbo, D. Doumtabe, Y. Kone, A. Traore.