Advertisement
Research Article

EBV Promotes Human CD8+ NKT Cell Development

  • He Yuling equal contributor mail,

    equal contributor Contributed equally to this work with: He Yuling, Xiao Ruijing, Ji Xiang, Li Li

    flying_bird2004@sina.com (HY); jinquan_tan@whu.edu.cn (TJ)

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Xiao Ruijing equal contributor,

    equal contributor Contributed equally to this work with: He Yuling, Xiao Ruijing, Ji Xiang, Li Li

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Ji Xiang equal contributor,

    equal contributor Contributed equally to this work with: He Yuling, Xiao Ruijing, Ji Xiang, Li Li

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Li Li equal contributor,

    equal contributor Contributed equally to this work with: He Yuling, Xiao Ruijing, Ji Xiang, Li Li

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Chen Lang,

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Xiong Jie,

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Section of Geriatrics, Departments of Internal Medicine, The Renmin University Hospital, Wuhan University, Wuhan, People's Republic of China

    X
  • Xiao Wei,

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Wang Yujuan,

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Zhang Lijun,

    Affiliation: Section of Geriatrics, Departments of Internal Medicine, The Renmin University Hospital, Wuhan University, Wuhan, People's Republic of China

    X
  • Zhou Rui,

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Tan Xinti,

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Bi Yongyi,

    Affiliation: Wuhan University School of Public Health, Wuhan, People's Republic of China

    X
  • Jiang Yan-Ping,

    Affiliation: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Jin Youxin,

    Affiliation: The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, People's Republic of China

    X
  • Tan Jinquan mail

    flying_bird2004@sina.com (HY); jinquan_tan@whu.edu.cn (TJ)

    Affiliations: Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China

    X
  • Published: May 20, 2010
  • DOI: 10.1371/journal.ppat.1000915

About the Authors

He Yuling, Xiao Ruijing, Ji Xiang, Li Li, Chen Lang, Xiong Jie, Xiao Wei, Wang Yujuan, Zhou Rui, Tan Xinti, Jiang Yan-Ping, Tan Jinquan
Department of Immunology, Wuhan University School of Medicine, Wuhan, People's Republic of China
Li Li, Chen Lang, Wang Yujuan, Zhou Rui, Tan Jinquan
Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China
Xiong Jie, Zhang Lijun
Section of Geriatrics, Departments of Internal Medicine, The Renmin University Hospital, Wuhan University, Wuhan, People's Republic of China
Bi Yongyi
Wuhan University School of Public Health, Wuhan, People's Republic of China
Jin Youxin
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, People's Republic of China

Corresponding Authors

Competing Interests

TJ, HY, XR, XW, LL, and WL have a patent pending on a method to establish the EBV-challenged human-thymus/liver-SCID chimera for NKT cell research and therapeutic usage.

Author Contributions

Conceived and designed the experiments: HY TJ. Performed the experiments: HY XR JX LL CL XJ XW WY ZL ZR TX BY JYP JY TJ. Analyzed the data: HY XR JX LL CL XJ XW WY ZL ZR TX BY JYP JY TJ. Wrote the paper: HY TJ.