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Research Article

Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control

  • Adam R. Hersperger,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Florencia Pereyra,

    Affiliation: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America

    X
  • Martha Nason,

    Affiliation: Biostatistics Research Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Korey Demers,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Prameet Sheth,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    X
  • Lucy Y. Shin,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    X
  • Colin M. Kovacs,

    Affiliation: Canadian Immunodeficiency Research Collaborative, Toronto, Ontario, Canada

    X
  • Benigno Rodriguez,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

    X
  • Scott F. Sieg,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

    X
  • Leia Teixeira-Johnson,

    Affiliation: Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Debbie Gudonis,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Paul A. Goepfert,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Michael M. Lederman,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

    X
  • Ian Frank,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • George Makedonas,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Rupert Kaul,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    X
  • Bruce D. Walker,

    Affiliations: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Michael R. Betts mail

    betts@mail.med.upenn.edu

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Published: May 27, 2010
  • DOI: 10.1371/journal.ppat.1000917

About the Authors

Adam R. Hersperger, Korey Demers, George Makedonas, Michael R. Betts
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Florencia Pereyra, Bruce D. Walker
Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America
Martha Nason
Biostatistics Research Branch, National Institutes of Health, Bethesda, Maryland, United States of America
Prameet Sheth, Lucy Y. Shin, Rupert Kaul
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Colin M. Kovacs
Canadian Immunodeficiency Research Collaborative, Toronto, Ontario, Canada
Benigno Rodriguez, Scott F. Sieg, Michael M. Lederman
Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America
Leia Teixeira-Johnson
Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, United States of America
Debbie Gudonis, Ian Frank
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Paul A. Goepfert
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Bruce D. Walker
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Corresponding Author

Email: betts@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ARH GM MRB. Performed the experiments: ARH KD. Analyzed the data: ARH MN. Contributed reagents/materials/analysis tools: FP PS LYS CMK BR SFS LTJ DG PAG MML IF RK BDW. Wrote the paper: ARH MRB. Intellectual support: GM BDW.