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Research Article

Effective, Broad Spectrum Control of Virulent Bacterial Infections Using Cationic DNA Liposome Complexes Combined with Bacterial Antigens

  • Robin Ireland,

    Affiliation: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • Norma Olivares-Zavaleta,

    Affiliation: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • Jonathan M. Warawa,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • Frank C. Gherardini,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • Clayton Jarrett,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • B. Joseph Hinnebusch,

    Affiliation: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • John T. Belisle,

    Affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Jeffery Fairman,

    Affiliation: Juvaris Biotherapeutics, Burlingame, California, United States of America

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  • Catharine M. Bosio mail

    bosioc@niaid.nih.gov

    Affiliation: Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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  • Published: May 27, 2010
  • DOI: 10.1371/journal.ppat.1000921

About the Authors

Robin Ireland, Norma Olivares-Zavaleta, Catharine M. Bosio
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
Jonathan M. Warawa, Frank C. Gherardini, Clayton Jarrett, B. Joseph Hinnebusch
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
John T. Belisle
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
Jeffery Fairman
Juvaris Biotherapeutics, Burlingame, California, United States of America

Corresponding Author

Email: bosioc@niaid.nih.gov

Competing Interests

A provisional patent for CLDC+MPF has been filed by NIH on behalf of Catharine M. Bosio, John T. Belise and Jeff Fairman.

Author Contributions

Conceived and designed the experiments: RI CMB. Performed the experiments: RI NOZ JMW CJ CMB. Analyzed the data: RI CMB. Contributed reagents/materials/analysis tools: FCG BJH JTB JF. Wrote the paper: CMB.