Advertisement
Research Article

The SOCS-Box of HIV-1 Vif Interacts with ElonginBC by Induced-Folding to Recruit Its Cul5-Containing Ubiquitin Ligase Complex

  • Julien R. C. Bergeron,

    Affiliations: Department of Infectious Diseases, King's College London School of Medicine, London, United Kingdom, Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

    X
  • Hendrik Huthoff,

    Affiliation: Department of Infectious Diseases, King's College London School of Medicine, London, United Kingdom

    X
  • Dennis A. Veselkov,

    Affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

    X
  • Rebecca L. Beavil,

    Affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

    X
  • Peter J. Simpson,

    Affiliation: Division of Molecular Biosciences, Imperial College London, London, United Kingdom

    X
  • Stephen J. Matthews,

    Affiliation: Division of Molecular Biosciences, Imperial College London, London, United Kingdom

    X
  • Michael H. Malim mail,

    michael.malim@kcl.ac.uk

    Affiliation: Department of Infectious Diseases, King's College London School of Medicine, London, United Kingdom

    X
  • Mark R. Sanderson

    Affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

    X
  • Published: June 03, 2010
  • DOI: 10.1371/journal.ppat.1000925

About the Authors

Julien R. C. Bergeron, Hendrik Huthoff, Michael H. Malim
Department of Infectious Diseases, King's College London School of Medicine, London, United Kingdom
Julien R. C. Bergeron, Dennis A. Veselkov, Rebecca L. Beavil, Mark R. Sanderson
Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom
Peter J. Simpson, Stephen J. Matthews
Division of Molecular Biosciences, Imperial College London, London, United Kingdom

Corresponding Author

Email: michael.malim@kcl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRCB SJM MHM MRS. Performed the experiments: JRCB RLB. Analyzed the data: JRCB RLB MHM MRS. Contributed reagents/materials/analysis tools: HH DAV PJS. Wrote the paper: JRCB MHM.