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Research Article

Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs

  • Yong-Qiang Zhang,

    Affiliation: The Johns Hopkins University School of Medicine of Baltimore, Maryland, United States of America

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  • Soledad Gamarra,

    Affiliation: Public Health Research Institute, New Jersey Medical School-UMDNJ, Newark, New Jersey, United States of America

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  • Guillermo Garcia-Effron,

    Affiliation: Public Health Research Institute, New Jersey Medical School-UMDNJ, Newark, New Jersey, United States of America

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  • Steven Park,

    Affiliation: Public Health Research Institute, New Jersey Medical School-UMDNJ, Newark, New Jersey, United States of America

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  • David S. Perlin,

    Affiliation: Public Health Research Institute, New Jersey Medical School-UMDNJ, Newark, New Jersey, United States of America

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  • Rajini Rao mail

    rrao@jhmi.edu

    Affiliation: The Johns Hopkins University School of Medicine of Baltimore, Maryland, United States of America

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  • Published: June 03, 2010
  • DOI: 10.1371/journal.ppat.1000939

About the Authors

Yong-Qiang Zhang, Rajini Rao
The Johns Hopkins University School of Medicine of Baltimore, Maryland, United States of America
Soledad Gamarra, Guillermo Garcia-Effron, Steven Park, David S. Perlin
Public Health Research Institute, New Jersey Medical School-UMDNJ, Newark, New Jersey, United States of America

Corresponding Author

Email: rrao@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YQZ SG GGE SP DSP RR. Performed the experiments: YQZ SG GGE SP. Analyzed the data: YQZ SG GGE SP DSP RR. Wrote the paper: YQZ DSP RR.