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Research Article

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

  • Bertram Bengsch equal contributor,

    equal contributor Contributed equally to this work with: Bertram Bengsch, Bianca Seigel

    Affiliations: Department of Medicine II, University of Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany

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  • Bianca Seigel equal contributor,

    equal contributor Contributed equally to this work with: Bertram Bengsch, Bianca Seigel

    Affiliations: Department of Medicine II, University of Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany

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  • Marianne Ruhl,

    Affiliation: Department of Virology, University of Essen, Essen, Germany

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  • Jörg Timm,

    Affiliation: Department of Virology, University of Essen, Essen, Germany

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  • Martin Kuntz,

    Affiliation: Department of Medicine II, University of Freiburg, Freiburg, Germany

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  • Hubert E. Blum,

    Affiliation: Department of Medicine II, University of Freiburg, Freiburg, Germany

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  • Hanspeter Pircher,

    Affiliation: Department of Immunology, University of Freiburg, Freiburg, Germany

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  • Robert Thimme mail

    Robert.Thimme@uniklinik-freiburg.de

    Affiliation: Department of Medicine II, University of Freiburg, Freiburg, Germany

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  • Published: June 10, 2010
  • DOI: 10.1371/journal.ppat.1000947

About the Authors

Bertram Bengsch, Bianca Seigel, Martin Kuntz, Hubert E. Blum, Robert Thimme
Department of Medicine II, University of Freiburg, Freiburg, Germany
Bertram Bengsch, Bianca Seigel
Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany
Bertram Bengsch, Bianca Seigel
Faculty of Biology, University of Freiburg, Freiburg, Germany
Marianne Ruhl, Jörg Timm
Department of Virology, University of Essen, Essen, Germany
Hanspeter Pircher
Department of Immunology, University of Freiburg, Freiburg, Germany

Corresponding Author

Email: Robert.Thimme@uniklinik-freiburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BB BS JT RT. Performed the experiments: BB BS MR MK. Analyzed the data: BB. Contributed reagents/materials/analysis tools: JT HEB HP RT. Wrote the paper: BB RT.