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Research Article

NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases

  • Bin Wu equal contributor,

    equal contributor Contributed equally to this work with: Bin Wu, Tatiana Skarina

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Tatiana Skarina equal contributor,

    equal contributor Contributed equally to this work with: Bin Wu, Tatiana Skarina

    Affiliation: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Adelinda Yee,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Marie-Claude Jobin,

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Rosa DiLeo,

    Affiliation: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Anthony Semesi,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Christophe Fares,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Alexander Lemak,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Brian K. Coombes,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Cheryl H. Arrowsmith,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Alexander U. Singer,

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Alexei Savchenko mail

    alexei.savchenko@utoronto.ca

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Published: June 24, 2010
  • DOI: 10.1371/journal.ppat.1000960

About the Authors

Bin Wu, Adelinda Yee, Anthony Semesi, Christophe Fares, Alexander Lemak, Cheryl H. Arrowsmith
Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada
Bin Wu, Adelinda Yee, Marie-Claude Jobin, Anthony Semesi, Christophe Fares, Alexander Lemak, Cheryl H. Arrowsmith, Alexander U. Singer, Alexei Savchenko
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Tatiana Skarina, Marie-Claude Jobin, Rosa DiLeo, Cheryl H. Arrowsmith, Alexander U. Singer, Alexei Savchenko
Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada
Brian K. Coombes
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: alexei.savchenko@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: B. Wu, T. Skarina, A. Yee, M. Jobin, A. Singer, A. Savchenko. Performed the experiments: T. Skarina, M. Jobin, R. DiLeo, A. Semesi, C. Fares. Analyzed the data: B. Wu, A. Yee, M. Jobin, A. Lemak, C. Arrowsmith, A. Singer, A. Savchenko. Contributed reagents/materials/analysis tools: T. Skarina, A. Semesi, A. Lemak, B. Coombes. Wrote the paper: B. Wu, T. Skarina, A. Yee, M. Jobin, A. Lemak, C. Arrowsmith, A. Singer, A. Savchenko.