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Research Article

Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis

  • Sixto M. Leal Jr,

    Affiliations: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Susan Cowden,

    Affiliation: Department of Plant Biology, University of Georgia, Athens, Georgia, United States of America

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  • Yen-Cheng Hsia,

    Affiliation: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Mahmoud A. Ghannoum,

    Affiliation: Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Michelle Momany,

    Affiliation: Department of Plant Biology, University of Georgia, Athens, Georgia, United States of America

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  • Eric Pearlman mail

    Eric.Pearlman@case.edu

    Affiliations: Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.ppat.1000976

About the Authors

Sixto M. Leal Jr, Yen-Cheng Hsia, Eric Pearlman
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
Sixto M. Leal Jr, Eric Pearlman
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
Susan Cowden, Michelle Momany
Department of Plant Biology, University of Georgia, Athens, Georgia, United States of America
Mahmoud A. Ghannoum
Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio, United States of America

Corresponding Author

Email: Eric.Pearlman@case.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SML EP. Performed the experiments: SML SC YCH. Analyzed the data: SML EP. Contributed reagents/materials/analysis tools: MAG MM. Wrote the paper: SML EP.