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Research Article

Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrPSc

  • Tamar Canello,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Kati Frid,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Ronen Gabizon,

    Affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Jerusalem, Israel

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  • Silvia Lisa,

    Affiliation: Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Assaf Friedler,

    Affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Jerusalem, Israel

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  • Jackob Moskovitz,

    Affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, United States of America

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  • María Gasset,

    Affiliation: Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Ruth Gabizon mail

    gabizonr@hadassah.org.il

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.ppat.1000977

About the Authors

Tamar Canello, Kati Frid, Ruth Gabizon
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
Ronen Gabizon, Assaf Friedler
Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Jerusalem, Israel
Silvia Lisa, María Gasset
Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Madrid, Spain
Jackob Moskovitz
Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, United States of America

Corresponding Author

Email: gabizonr@hadassah.org.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Tamar Canello, Ruth Gabizon. Performed the experiments: Tamar Canello, Kati Frid, Ronen Gabizon, Silvia Lisa, Ruth Gabizon. Analyzed the data: Tamar Canello, Kati Frid, Assaf Friedler, María Gasset, Ruth Gabizon. Contributed reagents/materials/analysis tools: Ronen Gabizon, Silvia Lisa, Assaf Friedler, Jackob Moskovitz, María Gasset. Wrote the paper: Tamar Canello, Ronen Gabizon, Jackob Moskovitz, María Gasset, Ruth Gabizon.