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Research Article

Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis

  • Don B. Gammon,

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

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  • Branawan Gowrishankar,

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

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  • Sophie Duraffour,

    Affiliation: Laboratory of Virology and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

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  • Graciela Andrei,

    Affiliation: Laboratory of Virology and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

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  • Chris Upton,

    Affiliation: Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

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  • David H. Evans mail

    devans@ualberta.ca

    Affiliation: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada

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  • Published: July 08, 2010
  • DOI: 10.1371/journal.ppat.1000984

About the Authors

Don B. Gammon, Branawan Gowrishankar, David H. Evans
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
Sophie Duraffour, Graciela Andrei
Laboratory of Virology and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
Chris Upton
Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

Corresponding Author

Email: devans@ualberta.ca

Competing Interests

Financial competing interest: A provisional U.S. patent application (No. 61/224,694) has been submitted by DBG and DHE entitled “Oncolytic Viruses and Methods for Treating Neoplastic Disorders” for the use of poxviruses deficient in ribonucleotide reductase genes as oncolytic agents.

Author Contributions

Conceived and designed the experiments: DBG DHE. Performed the experiments: DBG BG SD GA CU. Analyzed the data: DBG BG SD GA CU DHE. Wrote the paper: DBG DHE.