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Research Article

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication

  • Xiaonan Dong,

    Affiliation: Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, United States of America

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  • Hao Feng,

    Affiliation: Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, United States of America

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  • Qinmiao Sun,

    Affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Chao Yang District, Beijing, People's Republic of China

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  • Haiyan Li,

    Affiliation: Department of Microbiology and Immunology, Louisiana State University Health Science Center, Shreveport, Louisiana, United States of America

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  • Ting-Ting Wu,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Ren Sun,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Scott A. Tibbetts,

    Affiliation: Department of Microbiology and Immunology, Louisiana State University Health Science Center, Shreveport, Louisiana, United States of America

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  • Zhijian J. Chen,

    Affiliation: Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, United States of America

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  • Pinghui Feng mail

    Pinghui.Feng@UTSouthwestern.edu

    Affiliation: Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: July 29, 2010
  • DOI: 10.1371/journal.ppat.1001001

About the Authors

Xiaonan Dong, Hao Feng, Pinghui Feng
Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, United States of America
Qinmiao Sun
The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Chao Yang District, Beijing, People's Republic of China
Haiyan Li, Scott A. Tibbetts
Department of Microbiology and Immunology, Louisiana State University Health Science Center, Shreveport, Louisiana, United States of America
Ting-Ting Wu, Ren Sun
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
Zhijian J. Chen
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, United States of America

Corresponding Author

Email: Pinghui.Feng@UTSouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XD PF. Performed the experiments: XD HF HL PF. Analyzed the data: XD HL SAT PF. Contributed reagents/materials/analysis tools: XD HF QS TTW RS ZJC PF. Wrote the paper: XD SAT PF.