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Research Article

Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes

  • Vanessa Corby-Harris equal contributor,

    equal contributor Contributed equally to this work with: Vanessa Corby-Harris, Anna Drexler

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Anna Drexler equal contributor,

    equal contributor Contributed equally to this work with: Vanessa Corby-Harris, Anna Drexler

    Affiliation: Medical Microbiology and Immunology, University of California – Davis, Davis, California, United States of America

    X
  • Laurel Watkins de Jong,

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Yevgeniya Antonova,

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Nazzy Pakpour,

    Affiliation: Medical Microbiology and Immunology, University of California – Davis, Davis, California, United States of America

    X
  • Rolf Ziegler,

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Frank Ramberg,

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Edwin E. Lewis,

    Affiliations: Department of Entomology, University of California – Davis, Davis, California, United States of America, Department of Nematology, University of California – Davis, Davis, California, United States of America

    X
  • Jessica M. Brown,

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Shirley Luckhart,

    Affiliation: Medical Microbiology and Immunology, University of California – Davis, Davis, California, United States of America

    X
  • Michael A. Riehle mail

    mriehle@ag.arizona.edu

    Affiliation: Department of Entomology, University of Arizona, Tucson, Arizona, United States of America

    X
  • Published: July 15, 2010
  • DOI: 10.1371/journal.ppat.1001003

About the Authors

Vanessa Corby-Harris, Laurel Watkins de Jong, Yevgeniya Antonova, Rolf Ziegler, Frank Ramberg, Jessica M. Brown, Michael A. Riehle
Department of Entomology, University of Arizona, Tucson, Arizona, United States of America
Anna Drexler, Nazzy Pakpour, Shirley Luckhart
Medical Microbiology and Immunology, University of California – Davis, Davis, California, United States of America
Edwin E. Lewis
Department of Entomology, University of California – Davis, Davis, California, United States of America
Edwin E. Lewis
Department of Nematology, University of California – Davis, Davis, California, United States of America

Corresponding Author

Email: mriehle@ag.arizona.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL MAR. Performed the experiments: VCH AD LWdJ YA RZ FR JMB. Analyzed the data: VCH AD NP EEL. Wrote the paper: VCH AD NP SL MAR.