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Research Article

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

  • Kazuhide Onoguchi,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan, Graduate School of Science and Engineering, Waseda University, Tokyo, Japan

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  • Koji Onomoto,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Shiori Takamatsu,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Michihiko Jogi,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Azumi Takemura,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Shiho Morimoto,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Ilkka Julkunen,

    Affiliation: Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

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  • Hideo Namiki,

    Affiliation: Graduate School of Science and Engineering, Waseda University, Tokyo, Japan

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  • Mitsutoshi Yoneyama,

    Affiliations: Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba, Japan, PRESTO, Japan Science and Technology Agency, Saitama, Japan

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  • Takashi Fujita mail

    tfujita@virus.kyoto-u.ac.jp

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Published: July 22, 2010
  • DOI: 10.1371/journal.ppat.1001012

About the Authors

Kazuhide Onoguchi, Koji Onomoto, Shiori Takamatsu, Michihiko Jogi, Azumi Takemura, Shiho Morimoto, Takashi Fujita
Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan
Kazuhide Onoguchi, Shiori Takamatsu, Michihiko Jogi, Takashi Fujita
Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan
Kazuhide Onoguchi, Hideo Namiki
Graduate School of Science and Engineering, Waseda University, Tokyo, Japan
Ilkka Julkunen
Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
Mitsutoshi Yoneyama
Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba, Japan
Mitsutoshi Yoneyama
PRESTO, Japan Science and Technology Agency, Saitama, Japan

Corresponding Author

Email: tfujita@virus.kyoto-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Onoguchi, M. Yoneyama, T. Fujita. Performed the experiments: K. Onoguchi, K. Onomoto, S. Takamatsu, M. Jogi, A. Takemura, S. Morimoto. Analyzed the data: K. Onoguchi, H. Namiki, M. Yoneyama, T. Fujita. Contributed reagents/materials/analysis tools: I. Julkunen. Wrote the paper: K. Onoguchi, M. Yoneyama, T. Fujita.