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Research Article

Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and Ferrets

  • Marie-Ève Hamelin,

    Affiliation: CHUQ-CHUL Research Center in Infectious Diseases and Laval University, Québec City, Québec, Canada

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  • Mariana Baz,

    Affiliation: CHUQ-CHUL Research Center in Infectious Diseases and Laval University, Québec City, Québec, Canada

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  • Yacine Abed,

    Affiliation: CHUQ-CHUL Research Center in Infectious Diseases and Laval University, Québec City, Québec, Canada

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  • Christian Couture,

    Affiliation: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada

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  • Philippe Joubert,

    Affiliation: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada

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  • Édith Beaulieu,

    Affiliation: GlaxoSmithKline Biologicals, Laval, Québec, Canada

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  • Nathalie Bellerose,

    Affiliation: GlaxoSmithKline Biologicals, Laval, Québec, Canada

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  • Martin Plante,

    Affiliation: GlaxoSmithKline Biologicals, Laval, Québec, Canada

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  • Corey Mallett,

    Affiliation: GlaxoSmithKline Biologicals, Laval, Québec, Canada

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  • Gregg Schumer,

    Affiliation: National Microbiology Laboratory, Winnipeg, Manitoba, Canada

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  • Gary P. Kobinger,

    Affiliation: National Microbiology Laboratory, Winnipeg, Manitoba, Canada

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  • Guy Boivin mail

    Guy.Boivin@crchul.ulaval.ca

    Affiliation: CHUQ-CHUL Research Center in Infectious Diseases and Laval University, Québec City, Québec, Canada

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  • Published: July 22, 2010
  • DOI: 10.1371/journal.ppat.1001015

About the Authors

Marie-Ève Hamelin, Mariana Baz, Yacine Abed, Guy Boivin
CHUQ-CHUL Research Center in Infectious Diseases and Laval University, Québec City, Québec, Canada
Christian Couture, Philippe Joubert
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada
Édith Beaulieu, Nathalie Bellerose, Martin Plante, Corey Mallett
GlaxoSmithKline Biologicals, Laval, Québec, Canada
Gregg Schumer, Gary P. Kobinger
National Microbiology Laboratory, Winnipeg, Manitoba, Canada

Corresponding Author

Email: Guy.Boivin@crchul.ulaval.ca

Competing Interests

Corey Mallett, Édith Beaulieu, Nathalie Bellerose and Martin Plante are employees of the GlaxoSmithKline Company.

Author Contributions

Conceived and designed the experiments: MEH CM GPK GB. Performed the experiments: MB CC PJ EB NB GS. Analyzed the data: MEH MB YA CC PJ EB MP GS. Contributed reagents/materials/analysis tools: MH GB. Wrote the paper: MEH. Principal investigator: GB.