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Research Article

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

  • Laura M. Walker,

    Affiliation: Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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  • Melissa D. Simek,

    Affiliation: International AIDS Vaccine Initiative, New York, New York, United States of America

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  • Frances Priddy,

    Affiliation: International AIDS Vaccine Initiative, New York, New York, United States of America

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  • Johannes S. Gach,

    Affiliation: Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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  • Denise Wagner,

    Affiliation: IAVI AIDS Vaccine Design and Development Laboratory, Brooklyn, New York, United States of America

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  • Michael B. Zwick,

    Affiliation: Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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  • Sanjay K. Phogat,

    Affiliation: IAVI AIDS Vaccine Design and Development Laboratory, Brooklyn, New York, United States of America

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  • Pascal Poignard,

    Affiliation: Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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  • Dennis R. Burton mail

    burton@scripps.edu

    Affiliations: Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.ppat.1001028

About the Authors

Laura M. Walker, Johannes S. Gach, Michael B. Zwick, Pascal Poignard, Dennis R. Burton
Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America
Melissa D. Simek, Frances Priddy
International AIDS Vaccine Initiative, New York, New York, United States of America
Denise Wagner, Sanjay K. Phogat
IAVI AIDS Vaccine Design and Development Laboratory, Brooklyn, New York, United States of America
Dennis R. Burton
Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America

Corresponding Author

Email: burton@scripps.edu

Competing Interests

The authors declare competing financial interests. LMW, SKP, PP, and DRB are inventors on a patent describing the human broadly neutralizing antibodies PG9 and PG16 (U.S. provisional patent application numbers USSN 61/161,010; USSN 61/165,829; and USSN 61/224,739).

Author Contributions

Conceived and designed the experiments: LMW PP DRB. Performed the experiments: LMW JSG. Analyzed the data: LMW PP DRB. Contributed reagents/materials/analysis tools: MDS FP DW MBZ SKP DRB. Wrote the paper: LMW DRB.