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Research Article

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

  • Sophie A. Valkenburg,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Stephanie Gras,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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  • Carole Guillonneau,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Nicole L. La Gruta,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Paul G. Thomas,

    Affiliation: Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Anthony W. Purcell,

    Affiliation: Department of Biochemistry and Molecular Biology, the Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

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  • Jamie Rossjohn,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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  • Peter C. Doherty,

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia, Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Stephen J. Turner,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Katherine Kedzierska mail

    kkedz@unimelb.edu.au

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.ppat.1001039

About the Authors

Sophie A. Valkenburg, Carole Guillonneau, Nicole L. La Gruta, Peter C. Doherty, Stephen J. Turner, Katherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
Stephanie Gras, Jamie Rossjohn
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Paul G. Thomas, Peter C. Doherty
Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Anthony W. Purcell
Department of Biochemistry and Molecular Biology, the Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

Corresponding Author

Email: kkedz@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAV SG NLLG AWP JR PCD SJT KK. Performed the experiments: SAV SG CG NLLG KK. Analyzed the data: SAV SG CG PGT KK. Contributed reagents/materials/analysis tools: AWP JR KK. Wrote the paper: SAV SG CG NLLG PGT AWP JR PCD SJT KK.