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Research Article

Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection

  • Thomas J. Hannan,

    Affiliations: Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Indira U. Mysorekar,

    Affiliations: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Chia S. Hung,

    Affiliation: Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Megan L. Isaacson-Schmid,

    Affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Scott J. Hultgren mail

    hultgren@borcim.wustl.edu

    Affiliation: Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.ppat.1001042

About the Authors

Thomas J. Hannan, Chia S. Hung, Scott J. Hultgren
Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America
Thomas J. Hannan, Indira U. Mysorekar
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Indira U. Mysorekar, Megan L. Isaacson-Schmid
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: hultgren@borcim.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJH IUM SJH. Performed the experiments: TJH IUM CSH MLIS. Analyzed the data: TJH SJH. Wrote the paper: TJH SJH.