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Research Article

Bacteriophage Lysin Mediates the Binding of Streptococcus mitis to Human Platelets through Interaction with Fibrinogen

  • Ho Seong Seo,

    Affiliation: Division of Infectious Diseases, Veterans Affairs Medical Center and the University of California, San Francisco, California, United States of America

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  • Yan Q. Xiong,

    Affiliation: Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Jennifer Mitchell,

    Affiliation: University College, Dublin, Ireland

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  • Ravin Seepersaud,

    Affiliation: Division of Infectious Diseases, Veterans Affairs Medical Center and the University of California, San Francisco, California, United States of America

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  • Arnold S. Bayer,

    Affiliation: Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, United States of America

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  • Paul M. Sullam mail

    paul.sullam@ucsf.edu

    Affiliation: Division of Infectious Diseases, Veterans Affairs Medical Center and the University of California, San Francisco, California, United States of America

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.ppat.1001047

About the Authors

Ho Seong Seo, Ravin Seepersaud, Paul M. Sullam
Division of Infectious Diseases, Veterans Affairs Medical Center and the University of California, San Francisco, California, United States of America
Yan Q. Xiong, Arnold S. Bayer
Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California, United States of America
Jennifer Mitchell
University College, Dublin, Ireland

Corresponding Author

Email: paul.sullam@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HSS RS ASB PMS. Performed the experiments: HSS YQX JM RS. Analyzed the data: HSS ASB. Contributed reagents/materials/analysis tools: ASB PMS. Wrote the paper: HSS PMS.