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Research Article

Immune Modulation with Sulfasalazine Attenuates Immunopathogenesis but Enhances Macrophage-Mediated Fungal Clearance during Pneumocystis Pneumonia

  • Jing Wang,

    Affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Francis Gigliotti,

    Affiliations: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Samir P. Bhagwat,

    Affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Thaddeus C. George,

    Affiliation: Amnis Corporation, Seattle, Washington, United States of America

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  • Terry W. Wright mail

    Terry_Wright@urmc.rochester.edu

    Affiliations: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Published: August 19, 2010
  • DOI: 10.1371/journal.ppat.1001058

About the Authors

Jing Wang, Francis Gigliotti, Samir P. Bhagwat, Terry W. Wright
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
Francis Gigliotti, Terry W. Wright
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
Thaddeus C. George
Amnis Corporation, Seattle, Washington, United States of America

Corresponding Author

Email: Terry_Wright@urmc.rochester.edu

Competing Interests

Dr. George is an employee of Amnis Corporation, producers of the ImageStream imaging flow cytometer.

Author Contributions

Conceived and designed the experiments: JW FG SPB TWW. Performed the experiments: JW SPB. Analyzed the data: JW FG SPB TCG TWW. Wrote the paper: JW FG SPB TCG TWW.