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Research Article

A Rapid Change in Virulence Gene Expression during the Transition from the Intestinal Lumen into Tissue Promotes Systemic Dissemination of Salmonella

  • Sebastian E. Winter,

    Affiliations: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America, Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, München, Germany

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  • Maria G. Winter,

    Affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America

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  • Ivan Godinez,

    Affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America

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  • Hee-Jeong Yang,

    Affiliation: Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas, United States of America

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  • Holger Rüssmann,

    Affiliations: Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, München, Germany, HELIOS Klinikum Emil von Behring, Institut für Mikrobiologie, Immunologie und Laboratoriumsmedizin, Berlin, Germany

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  • Helene L. Andrews-Polymenis,

    Affiliation: Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas, United States of America

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  • Andreas J. Bäumler mail

    ajbaumler@ucdavis.edu

    Affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America

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  • Published: August 19, 2010
  • DOI: 10.1371/journal.ppat.1001060

About the Authors

Sebastian E. Winter, Maria G. Winter, Ivan Godinez, Andreas J. Bäumler
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America
Sebastian E. Winter, Holger Rüssmann
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, München, Germany
Hee-Jeong Yang, Helene L. Andrews-Polymenis
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas, United States of America
Holger Rüssmann
HELIOS Klinikum Emil von Behring, Institut für Mikrobiologie, Immunologie und Laboratoriumsmedizin, Berlin, Germany

Corresponding Author

Email: ajbaumler@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SEW HR HLAP AJB. Performed the experiments: SEW MGW IG HJY HLAP. Analyzed the data: SEW MGW IG HJY HR HLAP AJB. Wrote the paper: SEW AJB.