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Research Article

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

  • Rubén Agudo,

    Affiliation: Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

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  • Cristina Ferrer-Orta,

    Affiliation: Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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  • Armando Arias,

    Affiliation: Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

    Current address: Department of Virology, Imperial College London, London, United Kingdom

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  • Ignacio de la Higuera,

    Affiliation: Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain

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  • Celia Perales,

    Affiliations: Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

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  • Rosa Pérez-Luque,

    Affiliation: Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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  • Nuria Verdaguer,

    Affiliation: Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain

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  • Esteban Domingo mail

    edomingo@cbm.uam.es

    Affiliations: Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

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  • Published: August 26, 2010
  • DOI: 10.1371/journal.ppat.1001072

About the Authors

Rubén Agudo, Armando Arias, Ignacio de la Higuera, Celia Perales, Esteban Domingo
Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, Madrid, Spain
Cristina Ferrer-Orta, Rosa Pérez-Luque, Nuria Verdaguer
Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain
Celia Perales, Esteban Domingo
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

Corresponding Author

Email: edomingo@cbm.uam.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NV ED. Performed the experiments: RA CFO IdlH CP RPL. Analyzed the data: RA CFO AA IdlH CP NV ED. Contributed reagents/materials/analysis tools: AA. Wrote the paper: NV ED.