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Research Article

Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

  • Louise Joergensen,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Dominique C. Bengtsson,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Anja Bengtsson,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Elena Ronander,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Sanne S. Berger,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Louise Turner,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Michael B. Dalgaard,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Gerald K. K. Cham,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Michala E. Victor,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Thomas Lavstsen,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Thor G. Theander,

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • David E. Arnot,

    Affiliations: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark, Institute of Infection and Immunology Research, School of Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom

    X
  • Anja T. R. Jensen mail

    atrj@sund.ku.dk

    Affiliation: Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    X
  • Published: September 02, 2010
  • DOI: 10.1371/journal.ppat.1001083

About the Authors

Louise Joergensen, Dominique C. Bengtsson, Anja Bengtsson, Elena Ronander, Sanne S. Berger, Louise Turner, Michael B. Dalgaard, Gerald K. K. Cham, Michala E. Victor, Thomas Lavstsen, Thor G. Theander, David E. Arnot, Anja T. R. Jensen
Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
David E. Arnot
Institute of Infection and Immunology Research, School of Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom

Corresponding Author

Email: atrj@sund.ku.dk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LJ DCB LT TGT DEA ATRJ. Performed the experiments: LJ DCB AB ER SSB MBD MEV ATRJ. Analyzed the data: LJ DCB AB ER TGT DEA ATRJ. Contributed reagents/materials/analysis tools: LT GKKC TL. Wrote the paper: LJ DEA ATRJ.