Advertisement
Research Article

Generation of Neutralizing Antibodies and Divergence of SIVmac239 in Cynomolgus Macaques Following Short-Term Early Antiretroviral Therapy

  • Gülşen Özkaya Şahin equal contributor,

    equal contributor Contributed equally to this work with: Gülşen Özkaya Şahin, Emma J. Bowles

    Affiliation: Department of Laboratory Medicine, Lund University, Lund, Sweden

    X
  • Emma J. Bowles equal contributor,

    equal contributor Contributed equally to this work with: Gülşen Özkaya Şahin, Emma J. Bowles

    Affiliation: Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

    X
  • Joe Parker,

    Affiliation: Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

    X
  • Hannes Uchtenhagen,

    Affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

    X
  • Enas Sheik-Khalil,

    Affiliation: Department of Laboratory Medicine, Lund University, Lund, Sweden

    X
  • Stephen Taylor,

    Affiliation: Computational Biology Research Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

    X
  • Oliver G. Pybus,

    Affiliation: Department of Zoology, Oxford University, Oxford, United Kingdom

    X
  • Barbro Mäkitalo,

    Affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

    X
  • Lilian Walther-Jallow,

    Affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

    X
  • Mats Spångberg,

    Affiliation: Swedish Institute for Infectious Disease Control, Stockholm, Sweden

    X
  • Rigmor Thorstensson,

    Affiliation: Swedish Institute for Infectious Disease Control, Stockholm, Sweden

    X
  • Adnane Achour,

    Affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

    X
  • Eva Maria Fenyö,

    Affiliation: Department of Laboratory Medicine, Lund University, Lund, Sweden

    X
  • Guillaume B. E. Stewart-Jones ,

    Affiliation: Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom

    These authors also contributed equally to this work.

    X
  • Anna-Lena Spetz mail

    anna-lena.spetz@ki.se

    Affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden

    These authors also contributed equally to this work.

    X
  • Published: September 02, 2010
  • DOI: 10.1371/journal.ppat.1001084

About the Authors

Gülşen Özkaya Şahin, Enas Sheik-Khalil, Eva Maria Fenyö
Department of Laboratory Medicine, Lund University, Lund, Sweden
Emma J. Bowles, Joe Parker, Guillaume B. E. Stewart-Jones
Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom
Hannes Uchtenhagen, Barbro Mäkitalo, Lilian Walther-Jallow, Adnane Achour, Anna-Lena Spetz
Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
Stephen Taylor
Computational Biology Research Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, United Kingdom
Oliver G. Pybus
Department of Zoology, Oxford University, Oxford, United Kingdom
Mats Spångberg, Rigmor Thorstensson
Swedish Institute for Infectious Disease Control, Stockholm, Sweden

Corresponding Author

Email: anna-lena.spetz@ki.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GOS EJB JP HU OGP RT AA EMF GBESJ ALS. Performed the experiments: GOS EJB JP HU ESK MS. Analyzed the data: GOS EJB JP HU ESK ST BM LWJ RT EMF ALS. Contributed reagents/materials/analysis tools: ST BM LWJ. Wrote the paper: GOS EJB JP HU AA EMF GBESJ ALS.