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Research Article

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry

  • Carl J. Baldick mail,

    joe.baldick@bms.com

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Michael J. Wichroski,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Annapurna Pendri,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Ann W. Walsh,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Jie Fang,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Charles E. Mazzucco,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Kevin A. Pokornowski,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Ronald E. Rose,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Betsy J. Eggers,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Mayla Hsu,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

    Current address: Population Council, Center for Biomedical Research, New York, New York, United States of America

    X
  • Weixu Zhai,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Guangzhi Zhai,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Samuel W. Gerritz,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Michael A. Poss,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Nicholas A. Meanwell,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Mark I. Cockett,

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Daniel J. Tenney

    Affiliation: Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

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  • Published: September 02, 2010
  • DOI: 10.1371/journal.ppat.1001086

About the Authors

Carl J. Baldick, Michael J. Wichroski, Annapurna Pendri, Ann W. Walsh, Jie Fang, Charles E. Mazzucco, Kevin A. Pokornowski, Ronald E. Rose, Betsy J. Eggers, Mayla Hsu, Weixu Zhai, Guangzhi Zhai, Samuel W. Gerritz, Michael A. Poss, Nicholas A. Meanwell, Mark I. Cockett, Daniel J. Tenney
Bristol-Myers Squibb, Research and Development, Wallingford, Connecticut, United States of America

Corresponding Author

Email: joe.baldick@bms.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJB MJW AP CEM RER MH SWG MAP NAM DJT. Performed the experiments: CJB MJW AP AWW JF CEM KAP RER BJE MH WZ GZ. Analyzed the data: CJB MJW AP AWW JF CEM KAP RER BJE MH WZ GZ MIC. Contributed reagents/materials/analysis tools: CJB MJW AP AWW JF CEM KAP RER MH WZ. Wrote the paper: CJB DJT.