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Research Article

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect

  • Lucien Rufener,

    Affiliations: Novartis Centre de Recherche Santé Animale, St. Aubin, Switzerland, Institute of Cell Biology, University of Bern, Bern, Switzerland

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  • Jennifer Keiser,

    Affiliations: Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Ronald Kaminsky,

    Affiliation: Novartis Centre de Recherche Santé Animale, St. Aubin, Switzerland

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  • Pascal Mäser,

    Affiliations: Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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  • Daniel Nilsson mail

    daniel.nilsson@izb.unibe.ch

    Affiliation: Institute of Cell Biology, University of Bern, Bern, Switzerland

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  • Published: September 09, 2010
  • DOI: 10.1371/journal.ppat.1001091

About the Authors

Lucien Rufener, Ronald Kaminsky
Novartis Centre de Recherche Santé Animale, St. Aubin, Switzerland
Lucien Rufener, Daniel Nilsson
Institute of Cell Biology, University of Bern, Bern, Switzerland
Jennifer Keiser, Pascal Mäser
Swiss Tropical and Public Health Institute, Basel, Switzerland
Jennifer Keiser, Pascal Mäser
University of Basel, Basel, Switzerland

Corresponding Author

Email: daniel.nilsson@izb.unibe.ch

Competing Interests

L.R. and R.K. are employed by Novartis AH, which has developed monepantel. The use of AADs for veterinary purposes is patented (WO2002049641).

Author Contributions

Conceived and designed the experiments: LR JK RK PM DN. Performed the experiments: LR JK DN. Analyzed the data: LR JK RK PM DN. Contributed reagents/materials/analysis tools: LR JK DN. Wrote the paper: LR JK RK PM DN.