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Research Article

Pathogen Specific, IRF3-Dependent Signaling and Innate Resistance to Human Kidney Infection

  • Hans Fischer,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Nataliya Lutay,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Bryndís Ragnarsdóttir,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Manisha Yadav,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Klas Jönsson,

    Affiliation: Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology, and Research (A*STAR), Immunos, BIOPOLIS, Singapore, Singapore

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  • Alexander Urbano,

    Affiliation: Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology, and Research (A*STAR), Immunos, BIOPOLIS, Singapore, Singapore

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  • Ahmed Al Hadad,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Sebastian Rämisch,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Petter Storm,

    Affiliation: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden

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  • Ulrich Dobrindt,

    Affiliation: Institute for Molecular Biology of Infectious Diseases, Julius-Maximilians-University Würzburg, Würzburg, Germany

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  • Ellaine Salvador,

    Affiliation: Institute for Molecular Biology of Infectious Diseases, Julius-Maximilians-University Würzburg, Würzburg, Germany

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  • Diana Karpman,

    Affiliation: Department of Pediatrics, Clinical Sciences Lund, Lund University, and Lund University Hospital, Lund, Sweden

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  • Ulf Jodal,

    Affiliation: Pediatric-Uronephrology Center, Queen Silvia Children's Hospital, University of Gothenburg, Sweden

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  • Catharina Svanborg mail

    Catharina.Svanborg@med.lu.se

    Affiliations: Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden, Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology, and Research (A*STAR), Immunos, BIOPOLIS, Singapore, Singapore

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.ppat.1001109

About the Authors

Hans Fischer, Nataliya Lutay, Bryndís Ragnarsdóttir, Manisha Yadav, Ahmed Al Hadad, Sebastian Rämisch, Petter Storm, Catharina Svanborg
Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden
Klas Jönsson, Alexander Urbano, Catharina Svanborg
Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology, and Research (A*STAR), Immunos, BIOPOLIS, Singapore, Singapore
Ulrich Dobrindt, Ellaine Salvador
Institute for Molecular Biology of Infectious Diseases, Julius-Maximilians-University Würzburg, Würzburg, Germany
Diana Karpman
Department of Pediatrics, Clinical Sciences Lund, Lund University, and Lund University Hospital, Lund, Sweden
Ulf Jodal
Pediatric-Uronephrology Center, Queen Silvia Children's Hospital, University of Gothenburg, Sweden

Corresponding Author

Email: Catharina.Svanborg@med.lu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HF CS. Performed the experiments: HF NL BR MY KJ AU AAH SR PS. Analyzed the data: HF NL BR MY KJ AU AAH SR CS. Contributed reagents/materials/analysis tools: UD ES DK UJ CS. Wrote the paper: HF NL BR CS.